Kauai Hawaii – Reported by Elite Traveler the P

first_imgKaua’i, Hawaii – Reported by Elite Traveler, the Private Jet Lifestyle MagazineAs part of a new partnership with Malie Organics, the St. Regis Princeville Resort is offering a new bespoke spa experience, featuring completely customized holistic spa products, in the onsite Halele’a Spa.Malie Organics founder Dana Roberts will work one-on-one with guests to create custom-blended products that meet their own unique needs and preferences. Products from the company’s new Laha’ole Pure Rituals collection, designed exclusively for the resort, feature local ingredients like taro root, ginger, coffee berry and Kaua’i clay, all chosen for their healing properties.“Our goal is to develop completely unique spa experiences for our guests,” said Roberts. “Using only Hawaii’s freshest ingredients to make our products, we can design a fully customized program to best suit each client’s needs.”The Bespoke Spa Experience includes a private consultation with Roberts, which begins in the guest’s room with a selection of hand-blended Hawaiian hydrosols—tinctures that have been used for therapeutic purposes for centuries that are then mixed with champagne, water or juice for guests to sip on during the consultation process. Next, guests select their custom products before heading to the spa to enjoy treatments like a purifying bath soak, body exfoliation and lomi lomi massage. Post-treatment, the resort can ship products to a guest’s home so they can take a little piece of spa bliss back with them.To kick off the treatment’s launch, St. Regis is offering a Bespoke Spa Experience Package that includes a five-night stay in a St. Regis Suite, private consultation and treatments, daily breakfast and an oceanfront dinner for two, featuring spa-inspired cuisine.www.stregisaficionado.comlast_img read more

The wooden formwork has been taken off the wall an

first_imgThe wooden formwork has been taken off the wall and we see a collection of the clamps that held it in place. Notice the decoration at the top of wall. The impressions were made by wooden pieces fastened to the interior of the formwork. September 2, 2011August 3. to 8. 2011 was the last time we reported on the construction of an additional segment of the wall behind the metal shop. We can see a good photo of the wall form in the 8/5/2011 posting.The concrete wall has cured and construction staff and workshop participants are assembled to remove the formwork.center_img The crew.Photos were taken by planning intern Julie Pedtkelast_img read more

French ISP Iliad Telecom had 504 million broadban

first_imgFrench ISP Iliad Telecom had 5.04 million broadband subscribers at the end of March, up from 4.5 million a year earlier.The company’s Free subscriber base grew from 3.866 million to 4.72 million, while Alice customer numbers decreased from 638,000 to 320,000. During the quarter, 46,000 Alice customers migrated to Free-branded services.Iliad’s consolidated revenues increased by 28.6% to €655.7 million.last_img

first_img— — In those days the border was a more fluid concept. In 1917, Pershing lead 5,000 US cavalrymen deep into Mexico, chasing Villa after a raid he made into the US. That was about the time of the famous Zimmerman telegram, where the Germans promised help getting Texas, New Mexico and Arizona back to Mexico, if the Mexicans declared war on the US. That was one reason the Americans entered WW1. No matter… the Mexicans will get that land back without a formal attack.Justin: Interesting indeed. But back to the current situation…Doug: Right. Pershing and horse soldiers are long gone. Let me start by saying that the national guardsmen Trump proposes are basically weekend soldiers. These guys would rather be at home. They’d rather be working their day jobs. They’d rather spend time with their families. They’re not going to be happy about this.Plus, they’re unlikely to serve any useful purpose. Think about it. If they’re confronted by a large group of migrants, how are they going to stop them? Is it going to turn into a game of Red Rover? Or maybe a pushing contest?The only way they could stop a big group of migrants crossing the border is with real violence. But they won’t do that. That won’t happen.In other words, a large group of say 10,000 to 20,000 people, in unison, could easily walk across the border. Plus, understand that the people behind this mass migration aren’t stupid. They understand the dynamics. They know that a hundred migrants would just be a nuisance, to be rounded up and put in jail. You need the military principle of mass.Next time, maybe they’ll show up to the border with 50,000 people. That would be the equivalent of the Goths at Adrianople. That was 378 AD. After that, the barbarians totally inundated the Roman Empire from every angle. And in a generation they controlled every aspect of the Empire.If I wanted to collapse the US, that’s how I’d do it. Who needs the risks and expense of a conventional war? It would be neither hard nor very expensive to get a couple hundred thousand Salvadoreans, Hondurans, and what-have-you—not to mention Mexicans—to just human wave across the border. That would show the US is incapable of stopping anybody—except harassing some polite European tourists in airports, or polite Canadians driving across by car.Of course, there’d be a counter reaction. But things could easily spin out of control.Justin: And who do you think is behind all of this?Doug: Non-governmental organizations (NGOs) are certainly behind these migrants crossing the border. Poor peasants from Central America, or wherever—poor people and miscreants will show up from all over the world once the cat’s out of the bag—can’t act en masse. Today these people couldn’t cross the American border on their own. Or at most in onesies and twosies.Migrants don’t have the resources to support themselves. So they’re obviously getting help and funding from outside sources. I suspect it’s coming from NGOs. These people are politically and psychologically committed to destroying Western Civilization. And the average American or European has become so guilt-ridden, self-effacing, and philosophically corrupt that they welcome them.So, again, what they’ll try is sending 10,000, 50,000, or 200,000 people across the border. You couldn’t stop that many people. I don’t care if Trump puts up the National Guard; that will just add to the embarrassment. They’d just walk across the border, unless they’re machine-gunned. But the Guard is obviously not going to do that.I’d also gather as many pregnant women into the migrants as possible, both to create sympathetic photo-ops for the invading mob, and so their children could act as anchor babies. It would create chaos, which is exactly the desired effect.Most people don’t realize that the invasion that followed the Battle of Adrianople brought the Roman Empire to its knees within 30 years… They think that Rome fell in 476 AD, but that’s actually a meaningless date. It collapsed 60 or 70 years earlier, when the migrants totally washed everything away. Rome was just a shadow of its old self by the late Third Century. The army was mostly foreigners. Being a citizen no longer meant much. The government was bankrupt. The old values were being replaced by a new religion. There’s much more to be said. I suggest you look at a long article I did on this in December 2013 here.That exact same thing could happen in the States. And I don’t doubt that someone’s planning that already. There’s never been a better time to become a marijuana millionaire. The Pot Stock Millionaire Summit is willing to guarantee that they can give you the chance to see 500% gains from each of the 5 marijuana stocks that will be discussed during the Summit. The Summit is this Thursday, 8pm Eastern. It’s FREE for you to attend. Click here to reserve your spot to the event and get additional free training. **** 24245678 **** Justin’s note: Donald Trump wants to put 2,000–4,000 troops on the U.S.–Mexico border. And it’s no secret why he’s doing this. Trump wants to secure the borders. He believes that the “security of the United States is imperiled by a drastic surge of illegal activity on the southern border.”To be fair, this isn’t unprecedented. There have been three large-scale National Guard border missions since 2006. Still, I can’t help but wonder what might come out of this, given Trump’s strong views on illegal immigration.So, I called Doug Casey for his take on this issue…Justin: What do you make of this, Doug? Will deploying thousands of troops to the border curb illegal immigration?Doug: Well, it looks like what could have been a crisis has been temporarily defused. What might have been thousands of migrants rushing the border has apparently dwindled to a few stragglers. A non-event.But troubles on the Mexican border have a long and colorful pedigree. Especially starting from around 1912–1918. For one thing, one of my favorite authors, Ambrose Bierce, went to join Pancho Villa’s forces in 1913. He was in his 70s, and it was his way of checking out.There were some great movies made about that time and place, as well. Vera Cruz, with Burt Lancaster. The Professionals, with Burt Lancaster and Lee Marvin. And possibly my personal all-time favorite, The Wild Bunch, with William Holden. There’s even a fun comedy about the era, Three Amigos, with Steve Martin. Recommended Link What does 24245678 mean to you? For most folks, it’s just a bunch of numbers. But for you, knowing how to spot it could mean an easy $9,000 payout in the next few days. Click here immediately to see why. It’s TRUE! The Pot Stock Millionaire Summit is Offering the “5 for 500%” Pot Stock Guarantee As always, if you have any questions or suggestions for the Dispatch, send them to us right here.In Case You Missed It…A technology is being tested that has the potential to permanently cure thousands of diseases. It could even guarantee America’s energy independence for decades to come. It sounded too good to be true. But then we watched this presentation. Justin: Yeah, I’ve read a lot about NGOs doing the same thing in Europe. They’re literally moving Africans by the boatload to Europe, specifically Italy.Doug: These people have to be getting assistance. It’s not like they possess outboard motors, sails, or the skills to cross the Mediterranean. That’s serious business. So, they’re obviously getting help. But this has been happening for years.But who’s behind all this? Where’s the money coming from? We need to ask ourselves these questions because NGOs are destroying Western civilization. They’re run by busybodies looking to create chaos. And it’s in the interests of “charity.” Giving them money makes you a “philanthropist.”Justin: Why would they want to do that?Doug: It’s mostly a question of psychological aberration. Combined with perverse and bent philosophies. Universities today are filled with Marxist professors who despise Western civilization. Despite the fact Western civilization has brought us almost all the good things in life.It’s responsible for basically 100% of the world’s great literature, and 100% of the world’s great music. Free markets. Individualism. Liberty. The concept of human rights. The rule of law. Philosophy. Science. Technology. Almost all the noble ideas in the world. There are, to be sure, a few worthwhile things from other cultures. It’s been said that East minus West equals zero, but that’s going too far. I’m a fan of yoga, Taoism, and Oriental cuisine.Why would anyone want to destroy it? It’s a complete mystery to me. I don’t know what’s going on in these people’s heads. But I’ve spoken to people who hate Western civilization, and they’re apparently sincere about what they’re doing.So, maybe they’re just stupid. Look, I don’t care what their IQ score may be. These people are stupid on a very basic level.Justin: What do you mean by that?Doug: Well, we first need to define the word “stupid.” As I’ve said before, the best definition is an unwitting tendency to self-destruction; that’s what these people suffer from. Why? Perhaps they’re really very unhappy with themselves, but don’t have the courage or enough honest introspection to just put a gun to their heads. Hmm… maybe that’s another reason they’re universally antigun.There’s also a difference between intelligence and wisdom that’s lost on most people. Wisdom is the ability to calculate not just the immediate and direct consequences of actions. It doesn’t take much wisdom to make that calculation. The average six-year-old can do this. It’s not very deep.But you also must be able to contemplate the indirect and delayed consequences of your actions. And the people who run these NGOs seem incapable of that. They have absolutely no wisdom.That makes them stupid in my book. You could also say that they’re evil. But that word has also been discredited. A lot of religious types like to bandy it about. Their idea of “evil” is whatever goes against their god.But I’ve read the Bible. I’ve read the Quran. And I don’t think what passes for evil in those religious texts washes, quite frankly. To me, evil is being purposely destructive. And that’s what a lot of people who join these NGOs are.Sure, they pretend to be nice. They act like they’re doing all these wonderful things but they’re destroying civilization. They just can’t see it because they lack wisdom.The people populating NGOs and governments aren’t necessarily evil—even Mao, Pol Pot, Hitler, and Stalin felt they were good guys, doing the right thing. They’re just thoughtless and stupid.Justin: What about a desire for power control? It seems like that’s why a lot of people get involved in government and organizations like NGOs. They believe they’re best suited to shape society.Doug: You’re absolutely right. And they take control of society in many ways. They’re much more interested in controlling other people than they are in controlling physical things, however.Many of these same people naturally find their way into government. They enjoy pushing their fellows around. But, surprisingly to me, anyway, the average person seems to want that. They want a strong leader. They like hierarchy. They don’t mind being under the control of other people.All these socialists, social democrats, liberals, Democrats—their names are legion—think they’re doing the right thing. They think they’re being moral. And you can’t convince them otherwise. Intellectual arguments are useless against these people. It’s a psychological problem, not an intellectual one.You can’t make an intellectual argument to a mob.Justin: Thank you for taking the time to speak with me today, Doug.Doug: You’re welcome.Justin’s note: Most know Doug as a legendary crisis investor. But he’s also a “marijuana millionaire.” And tomorrow at 8 p.m. ET, he’s joining me and Crisis Investing editor Nick Giambruno to discuss why investors will be handed a rare second chance at investing in the marijuana market.This second wave is expected to be 8 times bigger than the first, when pot stocks were gaining 3,986%, 17,300%, 69,000%… even 299,000% and 399,000%. To hear from Doug himself on this exclusive FREE event—and why the time to strike is now—click here.Reader MailbagToday, a couple readers write in disagreeing with Doug’s take on nation states…I think “leave states and people alone” is always the best if done by example. What you are advocating is a loss of borders which is the moral equivalent of vanquishing one’s “body” (or your rights end where my body begins and vice versa), in favor of being “bodyless”. You cannot do away with the individual “anything”. A forest is a bunch of individual trees, first, last, and altogether. I don’t think the state is dead, but being transformed into its natural place, sovereign but equal nations.People right now can home school. People right now can form associations. People right now are waking up to this. People right now are beginning to see and not participate in the bloated state. But you seem to be advocating world government, at least you did in “part l” of your article. And, Doug, that is dangerous. And if your ideas don’t come about naturally with time, then world government it will be. A state much more horrid than nation states. And that is why I don’t agree. Westphalian National, sovereign states must be the next step or your ideas (which in and of themselves I agree with) will never come to pass. So please stop going around declaring that the “bordered” state, like the “bordered body” is dead. – Kay While there is some interesting material in this article, this statement is just very stupid: “Sure, he’s (Trump) done some pretty stupid things; his foreign policy of late borders on the criminally insane.” What things were “stupid”? I am not an American, so please tell me: Are you used to making empty statements and getting away with it without a challenge? And what about “his foreign policy of late ‘bordering’ on the ‘criminally insane’”? Challenging North Korea’s Kim Jong-un until he came to his senses? Bombing Syria for using chemical weapons?If you wish to consider gutless pile of sh*t foreign policy, look no further than the totally gutless wonder and complete pathological liar, Barack Obama, who like George W. Bush and Bill Clinton lacked the courage to challenge North Korea. As to the southern U.S. border he is entirely right, you need a wall. When you began spouting this drivel you destroyed the credibility of what you said earlier about nation states. – Rob Recommended Linklast_img read more

Madisonbased health care software company Wellbe

first_imgMadison-based health care software company Wellbe Inc. is working to raise $5 million from investors, according to a new SEC filing.The equity and debt round was launched Feb. 1, and so far includes 32 investors who have committed $4.6 million, according to the filing. James Dias, founder and chief executive officer of Wellbe, said the funding round is expected to close March 15. The lead investor in this round is WISC Partners.The new capital will be used “to drive growth and innovation in the company. Those are things that we would push for, really just scale our business up,” Dias said. Wellbe indicated “a portion of the total offering amount and the total amount sold is comprised of principal and interest from company-issued notes for which a separate Form D was not filed that were converted into the company’s equity securities.”Founded in 2009, Wellbe’s cloud-based platform provides integrated care delivery for hospitals and health care systems, with team coordination tools, case prioritization logic and alerts for immediate action. On the patient side, Wellbe has a user-friendly app that details action items they should take and provides health reminders. Wellbe was ranked at No. 322 in the 2016 Inc. 5000, with three-year growth of 1,201 percent and 2015 revenue of $2.2 million. At that time, it had 23 employees.But now, Wellbe has shrunk to 14 employees. Dias said the health care industry’s shift from pay-for-service to pay-for-performance, the space Wellbe’s platform targets, has been slower than expected.“We had anticipated as early as 2015 that payment reform would be a catalyst for creating demand for digital health technology to assist with patient programs,” he said. “When you’re in a pay-for-performance model and so much depends on the patient experience…these kind of connected technologies like the ones we have become much more important.“That sort of demand has not materialized because of changes in the administration, changes in the rules.”Dias declined to disclose Wellbe’s current revenue.“We haven’t seen the growth that we’ve been looking for. We are making some changes, introducing some new products, moving a little bit more to the revenue side of the equation,” he said.According to SEC filings, Wellbe has previously raised about $5 million in equity and debt from investors. Get our email updatesBizTimes DailyManufacturing WeeklyNonprofit WeeklyReal Estate WeeklySaturday Top 10Wisconsin Morning Headlines Subscribelast_img read more

A new research centre that plans to create a centr

first_imgA new research centre that plans to create a centre for “disability expertise” on the Olympic Park – as part of the London 2012 Paralympics legacy – has faced questions about its commitment to collaborating with local disabled people’s organisations (DPOs).The Global Disability Innovation Hub (GDIH) wants to spread innovative ideas across inclusive design, assistive technology, sport, arts and inclusive development and use the new centre as a “springboard for change” to improve the lives of disabled people in the UK and internationally.GDIH says it wants to ensure that disabled people are involved in the leadership of all of its programmes and to “promote that ethos and that way of working” internationally.Its aim, it says, is to “change the way we think about disability through co-design, collaboration, and innovation”, and to become “the leading place to come to research, study, practice and share disability innovations”.This week, the hub’s director, Vicki Austin, told Disability News Service (DNS) that she wanted GDIH to develop into a global centre for “disability expertise”, drawing on local communities, DPOs and disabled people.The hub launched last September, but only appointed its 15-strong board of directors – two-thirds of whom are disabled people – last week.It is moving its current base to University College London’s (UCL) new campus on the Olympic Park in east London.But despite its commitment to ensuring that disabled people lead its programmes, there are questions over its apparent failure to work with local disabled people and DPOs.When asked which DPOs it had worked with since its launch, Austin mentioned Together! 2012, which is led by the disabled artist and author Dr Ju Gosling, and has been working since the Paralympics to make the main London 2012 host borough of Newham into an international centre of excellence for disability arts.Together! 2012 is the most prominent DPO in the borough, and the only cultural organisation in east London to have been developed in response to the Paralympic legacy, while Gosling herself has an international reputation as a disabled artist, based in Newham, and is a leader on work looking at the relationship between disabled people and technology.But Gosling disputed Austin’s claims that the hub had been working with Together!, and said she had in fact been frustrated by her attempts to set up a meeting with GDIH, and had been trying to do so since January, in a series of emails seen by DNS.Her last emailed attempt to set up a meeting was on 16 May, which has still not received a reply from GDIH.She said: “They haven’t made any contact with us, and we have tried and tried and tried.“I find it discourteous and disrespectful and very disappointing. They clearly don’t know what co-production means.”A spokeswoman for the hub did not dispute the six-month delay in arranging a meeting, although she claimed that Austin had had “discussions” with Gosling as the hub was being developed.Austin said that GDIH had also been working closely with members of the Olympic Park’s built environment access panel (BEAP), and that it had been using them “as our initial sounding board”, as an interim arrangement before its board was appointed.One meeting was apparently held in the hub’s current home on the Olympic Park, so panel members could meet the team, while the panel’s chair, Peter Lainson, is a member of the hub’s working group, and two of his fellow disabled panel members have now been appointed to the GDIH board.But DNS has spoken to one member of the panel who said they were surprised to hear that GDIH was claiming such a close connection with BEAP, and believed the panel had not been involved with the hub in any significant way.The hub emerged from work at UCL and has some post-London 2012 funding from the London Legacy Development Corporation, although that is due to run out next year.None of GDIH’s other founding partners – the charity Leonard Cheshire Disability, the University of the Arts London’s London College of Fashion, Loughborough University in London, Saddler’s Wells Theatre, the Helen Hamlyn Centre for Design, and London’s Victoria and Albert Museum – are user-led organisations.The GDIH board will be led by the disabled Conservative peer Lord [Chris] Holmes, former disability commissioner for the Equality and Human Rights Commission, and London 2012’s director of Paralympic integration.He said he was “delighted” to be “part of a project with such potential to transform lives”.He said: “I have personally benefited from assistive technology and believe truly inclusive design not only removes barriers to disabled people but also, essentially, benefits everyone by leading to ground-breaking technological solutions or applications and truly excellent design.”Early GDIH projects include working with an “innovation lab” set up by a disabled people’s organisation in India and the International Committee of the Red Cross to develop new products to help disabled people, particularly in the global south.The hub is also involved in the development of a masters programme in disability design and innovation, which will begin in September 2018.Another project is the development of a digital/audio “wayfinding” tool that would help blind and partially-sighted visitors find their way around the Olympic Park.Austin said a crucial part of its approach was to ensure that disabled people were involved in leading its programmes. She said: “If there is an opportunity to amplify that message, and also the talents of those people, then that is what we intend and want to do.“We are particularly interested in harnessing the power of technology as it develops and a lot of that technology is being developed in institutions by non-disabled people.“If we are able to challenge some of that and engage people in both academic and non-academic programmes and also challenge some of the academic approaches in a way that puts co-creation and co-design right at the heart, not only are better products made but also it challenges the status quo.”Next month, the hub will host a disability innovation summit, running alongside the 2017 World Para-Athletics Championships, to “explore research and ideas, looking at innovation in tech, design, development, culture and art”.Picture: Lord Holmes at London Tech Week, after the announcement that he would be chairing GDIHlast_img read more

LinkedIn Just Completely Revamped Its Messaging Tool

first_img Kia Kokalitcheva 2 min read Image credit: aradaphotography | Shutterstock.com Linkedin Learn from renowned serial entrepreneur David Meltzer how to find your frequency in order to stand out from your competitors and build a brand that is authentic, lasting and impactful. –shares September 1, 2015 Add to Queuecenter_img This story originally appeared on Fortune Magazine LinkedIn Just Completely Revamped Its Messaging Tool Next Article If there’s one thing more annoying about the deluge of emails that LinkedIn, until very recently, sent to its users to get them to login, it’s the professional networking service’s antiquated “inbox” that makes email feel modern.And LinkedIn knows this, which is why on Tuesday it said that would roll out an entirely new inbox design for both mobile and desktop users. The revamped version is more akin to chat service Slack or your favorite messaging app, complete with emoji and GIFs.The overhaul is one is a series planned by CEO Jeff Weiner that will include new apps and services as well as redesigns of existing ones. The goal: entice users to not only log into LinkedIn more often, but also for longer. Or as Weiner puts it: providing more value for LinkedIn’s members.Image Credit: Courtesy of LinkedInLinkedIn’s design hasn’t changed much over the years, a reality that has started to alienate users. An attendee even created a somewhat uncomfortable moment at Fortune‘s Brainstorm Tech conference in July when he confronted co-founder and chairman Reid Hoffmann about the service’s design, or lack thereof.With the redesigned inbox, users will find invitations from others to connect in the “People you may know” section. Previously, they showed up as a message in the inbox. In addition to emoji and stickers, they’ll also be able to attach documents to their messages, and LinkedIn says it’s revamped how it sorts messages and how it notifies users of new ones via email and push notifications.Last month, LinkedIn LKND released Lookup, a mobile app that lets a company’s employees find coworkers by name, title, and skills by logging in with their work email address. The company came up with the idea after surveying 814 North American professionals, who largely said they didn’t find their company’s intranet helpful for this, and wished they could look for coworkers based on specific skills. In April, LinkedIn introduced Elevate, an app to help employees share company and industry content on LinkedIn and Twitter.And this is only the beginning. Fireside Chat | July 25: Three Surprising Ways to Build Your Brand Enroll Now for $5last_img read more

Targeting biochemical pathway may lead to new therapies for alleviating symptoms of

first_imgReviewed by James Ives, M.Psych. (Editor)Dec 12 2018According to some estimates, up to one in three people around the world may experience severe anxiety in their lifetime. In a study described today in Cell Reports, researchers at the Weizmann Institute of Science have revealed a previously unknown mechanism underlying anxiety. Targeting this biochemical pathway may help develop new therapies for alleviating the symptoms of anxiety disorders.The lab of Prof. Mike Fainzilber in the Institute’s Biomolecular Sciences Department has, for nearly two decades, studied the neuronal roles of proteins called importins. These proteins, found in all cells, shuttle molecules into the nucleus. The lab’s previous work focused on the peripheral nervous system (all nerve tissue in the body except the brain and spinal cord). Postdoctoral fellow Dr. Nicolas Panayotis, who joined the group in 2012, decided to find out whether any of the importins also play a role in the central nervous system, that is, the brain and spinal cord.Panayotis and colleagues studied five lines of mice, genetically engineered by Prof. Michael Bader’s laboratory in the Max Delbrück Center for Molecular Medicine in Berlin, to lack genes from the alpha subfamily of importins. The researchers subjected these mice to a battery of behavioral tests and found that one line of mice – those lacking importin alpha-5 – stood out in a unique manner: They showed no anxiety in stressful situations, for example, when they were placed in large, exposed arenas or on a highly elevated, open platform.The researchers then checked how these “calmer” mice differed from regular ones in terms of gene expression in certain brain regions involved in controlling anxiety. Computational analyses pointed to MeCP2, a regulatory gene known to affect anxiety behaviors. It turned out that importin alpha-5 was critical for enabling the entry of MeCP2 into the nuclei of neurons. Changes in the levels of MeCP2 in the nucleus, in turn, affected the levels of an enzyme involved in the production of a signaling molecule called S1P. In mice lacking importin alpha-5, MeCP2 failed to enter the nuclei of anxiety-controlling neurons, reducing S1P signaling and lowering anxiety.Related StoriesNew study explores link between traffic-related air pollution and childhood anxietySeasonal allergies to pollen occur more frequently in people with anxiety disordersNew study examines non‐medical use of anti-anxiety medicationAfter performing additional experiments to confirm that they had indeed discovered a new anxiety-regulating mechanism in the brain, the researchers searched for molecules that could modify this mechanism. They realized that drugs that modulate S1P signaling already exist; one such drug, fingolimod, is used to treat multiple sclerosis. When the researchers tested the effects of fingolimod on regular mice, these mice showed reduced anxiety, similarly to the genetically engineered mice lacking the importin alpha-5 gene. Moreover, the researchers found an earlier report from a clinical trial of fingolimod, according to which the drug had a calming effect on patients with multiple sclerosis. The new study might now help explain why this was the case.”Our findings have opened up a new direction for research into the mechanisms of anxiety,” Panayotis says. “If we understand exactly how the circuitry that we’ve discovered controls anxiety, this may help develop new drugs, or direct the use existing ones, to alleviate its symptoms.”Fainzilber: “Current drugs for anxiety are limited in their efficacy or have undesirable side effects, which also limit their usefulness. Our findings may help overcome these limitations. In follow-up research, we have already identified a number of drug candidates that target the newly discovered pathway.”The study’s findings also shed new light on rare genetic disorders characterized by mutations in the MeCP2 gene: Rett syndrome and MeCP2 duplication syndrome. Both these disorders are characterized by anxiety, among other symptoms. Identifying the precise mechanisms responsible for the entry of MeCP2 into neurons’ nuclei may, in the future, help develop therapies for these two disorders. Source:https://wis-wander.weizmann.ac.il/life-sciences/importins-anxietylast_img read more

Cobra Biologics announces appointment of Dr Darrell Sleep as Director of Innovation

first_imgI am excited to be joining Cobra, and working alongside its expert team at the Keele site. As part of the innovation group, I will be focusing on current and new processes, technologies and equipment, with the aim to further improve time and yields for customers, and to ultimately support them in making advanced therapies more accessible to patients.” Dr. Darrell Sleep, Director of Innovation The integration of Cobra’s innovation team, headed by Darrell as Director of Innovation, is key to establishing our UK site as a world-leading facility for ATMP production. Darrell’s extensive industry knowledge and expertise will be an invaluable addition to the Keele site management team.I am personally looking forward to working closely with him to continue to drive Cobra’s strong innovation agenda and to further enhance our profile as a leading scientific organization for the production of viral vectors and plasmid DNA.”Professor Daniel Smith, CSO Cobra Biologics Source:http://www.cobrabio.com/News/January-2019/cobra-biologics-director-of-innovation-darrellcenter_img Jan 16 2019Reviewed by Kate Anderton, B.Sc. (Editor)Cobra Biologics (Cobra), an international CDMO for biologics and pharmaceuticals, today announced the appointment of Dr. Darrell Sleep as Director of Innovation.The appointment is part of on-going strategic expansion activities currently underway at Cobra’s Keele site, to increase capacity and capability for both the clinical and commercial in-market supply of viral vector and DNA products to Advanced Therapy Medicinal Product (ATMP) developers.In his new role, Darrell will lead the site’s innovation team which has been newly formed from the integration of existing in-house R&D and Process Development expertise. The combined innovation team will deliver contract development activities to customers, in addition to driving scientific and technical innovation for new and existing service offerings.Darrell will work closely with Professor Daniel Smith, the Group’s Chief Scientific Officer (CSO), to streamline process workflows on the site, and facilitate timely adoption of pioneering bioprocess solutions. The appointment supports the rapid process development approaches required by Cobra’s advanced therapies customers, essential for cost-effective clinical and commercial manufacturing.Darrell has 30 years biopharmaceutical experience, with a proven record for leading innovation and product development.His industry experience includes 20 years in management positions where he successfully led a team to develop a new technology platform delivering pre-clinical in vivo proof-of-concept data sets, established techniques to improve therapeutic index and secured the relevant intellectual property to facilitate a number of successful collaborations with major pharma companies.Darrell has managed the development of improved production systems for a product, which following a technology transfer from R&D to Operations, successfully entered cGMP manufacture. Furthermore, he is co-inventor of a technology platform designed to improve the circulatory half-life of biotherapeutic drugs, leading to the development of approved biologics, and generating royalties over $30 million by end 2017.last_img read more

Measles vaccination associated with health schooling benefits among children

first_imgRelated StoriesRevolutionary gene replacement surgery restores vision in patients with retinal degenerationChaos in the house and asthma in children – the connectionNew network for children and youth with special health care needs seeks to improve systems of careThe study found that at ages 7-8 years, measles-vaccinated children had significantly higher HAZ scores in India (an increase of 0.13 points, P=0.05), and significantly higher BMIZ and WAZ scores in Vietnam (an increase of 0.18 and 0.23 points, P=0.04, 0.01 ) as compared with matched measles-unvaccinated children. Measles-vaccinated children scored 2.3, 2.5, and 2.7 points more on EGRA in Ethiopia, India, and Vietnam, respectively. Vaccinated children scored 4.5 and 2.6 percentage points (pp) higher on PPVT and 2.9 and 4.0 pp higher on mathematics in Ethiopia and Vietnam.Similarly, at ages 11-12 years, measles-vaccinated children had 0.19 higher BMIZ scores in Vietnam (P= 0.04), and they scored 3 pp more on English and PPVT in India. Vaccinated children also attained 0.2-0.3 higher schooling grades across all ages and countries compared to measles-unvaccinated children.Findings indicate that measles vaccination at 6-18 months of life is associated with long-term health, cognition, and schooling benefits among children in Ethiopia, India, and Vietnam.”As a pediatrician and parent myself, I feel confident that these results will show other parents and medical workers how the measles vaccine may help their children achieve better health and educational outcomes.”, said Anita Shet, who is a coauthor of the study and a pediatric infectious disease specialist at the International Vaccine Access Center, Johns Hopkins Bloomberg School of Public Health.CDDEP director Ramanan Laxminarayan, a coauthor of the study, said, “At a time when there is hesitation about measles vaccination by parents, the results of this study are an important reminder that the benefits of measles vaccination go beyond child survival and are instrumental in enabling adults who have higher cognitive ability, education and physical stature. These are critical to economic development that every country aspires to.” Source:Center for Disease Dynamics, Economics & PolicyJournal reference:Nandi, A. et al. (2019) Anthropometric, cognitive, and schooling benefits of measles vaccination: Longitudinal cohort analysis in Ethiopia, India, and Vietnam. Vaccine. doi.org/10.1016/j.vaccine.2019.06.025. Reviewed by Alina Shrourou, B.Sc. (Editor)Jun 21 2019While the measles vaccine has eliminated the virus in many high-income countries, the global burden of disease persists with an estimated 245,000 measles cases and 68,000 measles-associated deaths worldwide in 2016. India alone accounted for 50 percent of measles cases and 30 percent of measles deaths in 2016. Although low- and middle-income countries (LMICs) account for a large proportion of global measles cases, high-income countries have recently seen a resurgence of measles outbreaks.According to the US Centers for Disease Control and Prevention (CDC), there have been over 1,000 measles cases reported across 28 states in the US so far in 2019. This is the largest number of cases the country has seen in almost 3 decades, and since measles was eliminated in 2000. Despite these recent setbacks, the highly efficacious and cost-effective measles vaccine prevented an estimated 21.1 million child deaths worldwide between 2000-2017. The vaccine has also been tied to reductions in all-cause childhood mortality and infectious disease morbidity outcomes in LMICs, although little generalizable evidence exists on the early-life receipt of measles vaccines and associated child growth parameters, cognition, and schooling grades.Researchers examined Z- scores of height-for-age (HAZ), BMI-for-age (BMIZ), weight-for-age (WAZ), scores of Peabody Picture Vocabulary Test (PPVT), early grade reading assessment (EGRA), language and mathematics tests, and highest schooling attainment across ~6,000 measles-vaccinated and unvaccinated children in Ethiopia, India, and Vietnam. Propensity score matching methods were used to reduce the effects of potential confounding factors.Researchers analyzed survey data from 3 cohorts of children enrolled in the Young Lives Survey (YLS), a longitudinal study assessing childhood poverty. Growth, cognitive, and schooling indicators were evaluated across measles-vaccination groups, and outcomes at ages 7-8 and 11-12 years were compared between children across the 3 countries with reported receipt or non-receipt of measles vaccination at 6-18 months of life. We reviewed children who were followed since infancy through childhood and used statistical techniques that produced robust estimates of the associations of measles vaccination with later life outcomes. It is the first and the largest multi-country study of its kind.”CDDEP senior fellow Arindam Nandi, the lead author of the studylast_img read more

German unions call for strike against Ryanair Wednesday

first_img Citation: German unions call for strike against Ryanair Wednesday (2018, September 11) retrieved 17 July 2019 from https://phys.org/news/2018-09-german-unions-ryanair-wednesday.html © 2018 AFP The strike, which is expected to last 24 hours, would involve some 400 Ryanair pilots and co-pilots in Germany Explore further The pilots’ Cockpit union said in a statement Monday that they have been demanding these improvements “for months”. Despite the “clear signal” given during the strikes in August, “the negotiations remain deadlocked. We demand finally some solutions,” said Ingolf Schumacher, in charge of salary negotiations for the union.The strike, which is expected to last 24 hours, would involve some 400 Ryanair pilots and co-pilots in Germany.About 1,000 flight personnel in the country have also called for a work stoppage on Wednesday.”The salaries are so low they do not guarantee a sufficient living wage,” said Christine Behle of the German services union in a separate statement. In August, Ryanair, which carries some 130 million passengers annually, had to cancel 250 flights to and from Germany after the German pilots joined a pan-Europe strike against the airline.Meanwhile, Ryanair reached agreements with personnel in Ireland and Italy, which Germany’s Cockpit union considers insufficient.While the carrier is for the first time recognising unions across Europe that represent its pilots and cabin crew, staff are unhappy that improvements have yet to be made on pay and other conditions.center_img Ryanair recognises cabin crew union in Ireland Unions representing pilots and cabin crew of Irish no-frills airline Ryanair In Germany have called for a strike on Wednesday over better pay and working conditions. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Monsoon flooding forces thousands from their homes in Myanmar

first_img Nation 11 Jul 2019 China’s training on disaster management sought Related News World 10 Jul 2019 Singapore detains Myanmar nationals accused of links to Arakan Army Related News YANGON (Reuters) – Days of heavy monsoon rain and dangerously high river levels in Myanmar have forced more than 18,000 people from their homes and flooded at least one camp for people displaced by recent fighting, authorities and a politician said on Monday.Four towns along the Ayeyarwady and Chindwin rivers were in danger of being inundated as the rivers rose, the Department of Disaster Management said.”We are working together with local authorities helping the people and providing food,” said the department’s director, Phyu Lai Lai Htun. More people were expected to be forced from their homes on Monday, she said. AdChoices广告Heavy downpours hit the tropical Southeast Asian country during the May-October rainy season, often triggering flooding.The northern state of Kachin was the worst affected, with 14,000 people forced from their homes near the banks of the Ayeyarwady river.Media published photographs showing submerged houses, vehicles and roads in Myitkyina, the state’s capital.Flooding also forced 3,000 people in the western Rakhine state to relocate, the disaster management department said.They included some of the thousands displaced by fighting between the military and the Arakan Army insurgent group since late last year, according to Tun Aung Kyaw, secretary of the Arakan National Party, who visited a camp for several hundred displaced people near the ancient city of Mrauk-U.”The whole camp is flooded and people are desperately in need of immediate shelter and food,” he told Reuters by telephone.Myanmar has restricted access to the conflict zone for most international aid agencies.The U.N. Office for the Coordination of Humanitarian Affairs said in a Facebook post it was helping the government respond to the flooding, while the Myanmar Red Cross, aid groups and private donors were also aiding the victims.”We are working closely with authorities and stand ready to support the government’s response,” Knut Ostby, the UN resident and humanitarian coordinator, said on Twitter. (Reporting by Shoon Naing; Editing by Robert Birsel) World 16h ago Death toll in Nepal floods rises to 55, thousands displaced {{category}} {{time}} {{title}}last_img read more

Five sent to hospital on sixth day of Pamplona bull run

first_img World 11 Jul 2019 One gored among seven hurt on fifth day of Pamplona bull-running Related News World 07 Jul 2019 Three people gored on first day of Spanish bull-running festival {{category}} {{time}} {{title}} The bulls are later killed in the bull ring by matadors. (Reporting by Susana Vera; writing by Paul Day; editing by Jason Neely)center_img PAMPLONA, Spain (Reuters) – One man was gored and at least four other people were sent to hospital with injuries following the sixth day of the running of the bulls at the San Fermin festival in the northern Spanish city of Pamplona, the Red Cross said on Friday. Each morning at 8 a.m. (0600 GMT) between July 7 and 14 as part of the week-long festival thousands line the streets of the medieval city to take part in the centuries-old tradition of running with the bulls. In the 875-metre chase through the narrow streets of the city a half dozen, specially bred, aggressive bulls, led by six larger, more docile steers race from their pen to the city’s bull ring as runners dodge horns and stampeding hooves. Friday’s run lasted just two minutes and 18 seconds, though most runners sprint just briefly before being overtaken by the herd. Related News World 05 Jul 2019 ‘Speared’ activists protest Spain’s Pamplona bull runslast_img read more

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